| 职称职务： |
中国科学院院士、教授、亚搏App入口副校长 |
|
|
专 业： |
细胞生物学、分子免疫学 |
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研究方向： |
抗病毒天然免疫 |
|
实 验 室： |
4003 |
|
Email: |
shuh@whu.edu.cn |
教育经历
1983-1987 兰州大学生物学系动物学专业，学士
1987-1990 中国医学科学院基础医学研究所细胞生物学研究室，硕士
1992-1995 美国Emory大学细胞及发育生物学专业，博士
1995-1997 美国Tularik公司（后并入Amgen公司）David Goeddel实验室，博士后
工作经历与任职
1990-1992 美国密西根大学医学中心，研究助理
1997-1998 美国Magainin制药公司，资深科学家
1998-2003 美国犹太医学研究中心及科罗拉多大学健康科学中心免疫学系，助理教授
2003-2005 美国犹太医学研究中心及科罗拉多大学健康科学中心免疫学系，副教授
2005-2013 亚搏App入口，教授、院长
2013- 亚搏App入口副校长，亚搏App入口教授
学术兼职
Journal of Biological Chemistry编委（2007-2012）
Cell Research编委（2010-）
Journal of Molecular Cell Biology副主编（2009-）
Frontiers in Biology副主编（2009-）
Protein & Cell编委（2009-）
中国科学C辑－生命科学编委（2008-2013）
中国细胞生物学学会副理事长、免疫细胞生物学分会会长（2007-）
湖北省细胞生物学学会理事长（2007-）
中国免疫学会理事（2006-）
中国生物物理学学会理事 (2009-)
国家自然基金委生命科学部第四届专家咨询委员会委员（2008-2011）
第六、七届国家杰出青年基金评审委员会委员 （2009-2014）
国家自然基金委/中科院“12.5生物学学科发展战略研究”专家组成员、秘书组组长(2009-2010)
国家自然基金委生命科学部细胞生物学学科专家评审组成员(2006-2009)
国家自然基金委生命科学部免疫学学科专家评审组成员(2012-)
国家自然科学基金委员会“抗病毒天然免疫”创新研究群体带头人（2009-）
国家重大基础研究计划973项目“感染与免疫的基础研究”首席科学家（2006-2010）
蛋白质科学国家重大科学研究计划项目“天然免疫相关蛋白的鉴定、结构和功能”首席科学家（2012）
获奖及荣誉
中国科学院院士（2011）
发展中国家科学院院士（2012）
第十二届全国政协委员（2013）
国家自然科学二等奖（第一完成人，2010）
中国细胞生物学学会－CST杰出成就奖（首届, 2009）
谈家祯生命科学创新奖（2009）
中国教育部自然科学奖一等奖 (第一完成人, 2005)
万人计划科技创新领军人才入选者（2013）
国家杰出青年基金获得者（1999）
中国侨界贡献奖（2012）
新世纪百千万人才工程国家级人。2007）
第四届湖北省优秀科技工作者 (2008)
武汉市优秀留学回国人员（2011）
亚搏App入口研究生教育杰出贡献奖（2012）
亚搏App入口合校10周年十大风云人物（2010）
亚搏App入口10大“我心目中的好导师”（2010）
亚搏App入口“十大师德标兵”（2007）
美国白细胞生物学学会Dolph Adams奖（2004）
美国犹太医学及研究中心首届“杰出青年教授奖”（2001）
美国Harmon基金会Harmon关节炎研究奖（2001）
美国Ellison医学基金会新学者奖（2000）
研究资助
获得国家科技部973项目、863项目、国家自然基金重点项目、国家杰出青年基金、国家自然基金委创新研究群体项目等资助。
发表论文概况
已在国际刊物发表论文101篇。据googlescholar搜索，这些论文已被引用10000余次，其中单篇被引用超过100次的论文20篇。通讯作者论文单篇最高被引用915次，第一作者论文单篇最高被引用397次。
代表性论文（55 out of 101）
1. Shu HB, Agranoff A, Nabel EG, Leung K, Neish AS, Collins , Nabel GJ* (1993). Differential regulation of VCAM-1 gene expression by specific NF-kB subunits in endothelial and epithelial cells. Mol Cell Biol 13:6283-6289.
2.
Shu HB, Li Z, Palacios MJ, Li Q, Joshi HC* (1995). A transient association of g-tubulin at the midbody is required for the completion of cytokinesis during the mammalian cell division.
J Cell Sci 108: 2955-2962.
3.
Shu HB , Joshi HC* (1995). g-Tubulin can both neacleate microtubule assembly and self-assemble into tubular structures in mammalian cells.
J Cell Biol 130:1137-1147.
4. Hsu H,
Shu HB, Pan MG, Goeddel DV* (1996). TRADD-TRAF2 and TRADD-FADD interactionss define two distinct TNF receptor-1 signal transduction pathways.
Cell 84:299-308.
5.
Shu HB, Takeuchi M, Goeddel DV* (1996). The TNF receptor 2 signal transducers TRAF2 and c-IAP1 are components of the TNF receptor 1 signaling complex.
P Natl Acad Sci USA 93:13973-13978.
6.
Shu HB, Halpins DR, Goeddel DV* (1997). Casper is a FADD and Caspase-related Inducer of Apoptosis.
Immunity 6:751-763.
7
. Yeh WC, Pompa JL, McCurrach ME,
Shu HB, Elia AJ, Shahinian A, Ng M, Wajegam A, Mithchell K, El-Deiry WS, Lowe SW, Goeddel DV M,ak TW* (1998). FADD: essential for embryonic development and signaling from some, but not all, inducers of apoptosis.
Science279:1954-1958.
8.
Shu HB*, Hu WH, Johnson H (1999). TALL-1 is a novel member of the TNF family that is downregulated by mitogens.
J Leukocyte Biol 65:680-683.
9.
Hu WH, Johnson H,
Shu HB* (1999). TRAIL signal NF-kB and JNK activation and apoptosis through distinct pathways
. J Biol Chem274:30603-30610.
10. Hu WH, Johnson H,
Shu HB* (2000). Activation of NF-kB by FADD, Casper and Caspase-8.
J Biol Chem 275:10838-10844.
11.
Shu HB*, Johnson H (2000). BCMA is a receptor for the TNF family member TALL-1.
P Natl Acad Sci USA 97:9156-9161.
12. Chen D, Li X, Zhai Z,
Shu HB* (2002).
A novel zinc finger protein interacts with RIP and inhibits TNF- and IL-1-induced NF-kB activation.
J Biol Chem. 277:15985-15991.
13. Liu Y, Xu L, Opalka N, Kappler J,
Shu HB, Zhang G* (2002). Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands.
Cell 108: 383-394.
14. Wu M, Xu L, Li X, Zhai Z ,
Shu HB* (2002). AMID, an AIF homologous mitochondrion-associated protein, induces caspase-independent apoptosis
. J Biol Chem 277:25617-25623.
15. Xu L,
Shu HB* (2002). TRAF3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kB activation and IL10 production.
J Immunol 169: 6883-6889.
16. Chen D, Xu LG, Chen L, Li L, Zhai Z, and
Shu HB* (2003). NIK is a component of the EGF/Heregulin receptor signaling complex.
Oncogene 22:4348-4355.
17. Wu M, Xu L, Zhai Z,
Shu HB* (2003). SINK: a p65-interacting protein that negatively regulates NF-kB-dependent transcription
. J Biol Chem 278:27072-27079.
18. Bin L, Xu L,
Shu HB* (2003). TIRP: a novel TIR domain-containing adapter protein involved in toll/interleukin-1 receptor signaling
. J Biol Chem 27:24526-24532.
19. Bin L, Nielson LD, Liu X, Mason RJ,
Shu HB* (2003). Identification of UGRP1 and MARCO as a lung-specific ligand-receptor pair.
J Immunol 171:924-930.
20. Zhang J, Xu LG, Han KJ,
Shu HB* (2004). Identification of a ZU5 and death domain containing inhibitor of NF-kB.
J Biol Chem279:17819-17825.
21. Han KJ, Su X, Xu LG, Bin LH, Zhang J,
Shu HB* (2004). Mechanisms of TRIF-induced ISRE and NF-kappa B activation and apoptosis pathways.
J Biol Chem 279:15652-15661.
22. Huang J, Teng L, Li L, Liu T, Li L, Chen D, Xu LG, Zhai Z,
Shu HB* (2004). ZNF216 is an A20-like and IKKgamma -interacting inhibitor of NF-kappa B activation.
J Biol Chem 279:16847-16853.
23. Xu LG, Li LY,
Shu HB* (2004). TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis.
J Biol Chem279:17278-17282.
24. Wu M, Xu LG, Su T, Huang J, Zhai Z,
Shu HB* (2004). AMID is a p53-inducible gene down-regulated in tumors.
Oncogene 23:6815-6819.
25. Li L, Bin LH, Li F, Liu Y, Chen D, Zhai Z,
Shu HB* (2005). TRIP6 is a RIP2-associated common signaling component of multiple NF-kB activation pathways.
J Cell Sci 118:555-563.
26. Xu LG, Wang YY, Han KJ, Li LY, Zhai Z,
Shu HB* (2005). VISA is an adapter protein required for virus-triggered signaling.
Mol Cell 19:727-740
.
27. Huang J, Liu T, Chen D, Zhai Z,
Shu HB* (2005). SIKE is an IKK-relative kinases-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.
EMBO J 24:4018-4028.
28. Zha J, Han K, Xu LG, Zhou Q, Chen D, Zhai Z,
Shu HB* (2006). The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IKK family members.
J Immunol 176:1072-1080.
29. Tian Y, Zhang Y, Zhong B, Wang YY, Diao FC, Wang RP, Zhang M, Chen DY, Zhai ZH,
Shu HB* (2007). RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation.
J Biol Chem 282:16776-16782.
30. Diao F, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Chen D, Zhai Z, Zhong B, Tien P,
Shu HB* (2007). Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase.
P Natl Acad Sci USA 104:11706-11711.
31. Zhang M, Tian Y, Wang RP, Gao D, Zhang Y, Diao FC, Chen DY, Zhai ZH,
Shu HB* (2008). Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3.
Cell Res 18:1096-1014.
32. Zhang B, Huang J, Li HL, Liu T, Wang YY, Waterman P, Mao AP, Xu LG, Zhai Z, Liu D, Marrack P,
Shu HB* (2008). GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth.
Cell Res 18:900-910.
33. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F, Lei C, He X, Zhang L, Tien P,
Shu HB* (2008). The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation.
Immunity 29:538-550.
34. Zhong B, Zhang L, Lei Z, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL,
Shu HB* (2009). RNF5 negatively regulates virus-induced IRF3 activation via ubiquitination and degradation of MITA.
Immunity 30:397-407.
35. Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang F,
Shu HB* (2009). ISG56 is a negative feedback regulator of virus-triggered signaling and cellular antiviral response.
P Natl Acad Sci USA 106:7945-7950.
36. Wang YY, Liu LJ, Zhong B, Liu TT, Li Y, Yang Y, Ran Yong, Li S, Tien P,
Shu HB* (2010). WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kB activation.
P Natl Acad Sci USA 107:815-820.
37. Li S, Zheng H, Mao AP, Zhong B, Li Y, Liu Y, Gao Y, Ran Y, Tien P,
Shu, HB* (2010). Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6.
J Biol Chem 285:4291-4297.
38. Mao AP, Li S, Zhong B, Li Y, Yan J, Li Q, Teng C,
Shu HB* (2010). Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response.
J Biol Chem 285:9470-9476.
39. Han KJ, Yang Y, Xu LG,
Shu HB* (2010). Analysis of a TIR-less splice variant of TRIF reveals an unexpected mechanism of TLR3-mediated signaling.
J Biol Chem 285:12543-12550.
40. Chen R, Zhang L, Zhong B, Tan B, Liu Y,
Shu HB* (2010). The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.
Cell Res 20:802-811.
41. Zhong B, Zhang Y, Tan B, Liu TT, Wang YY,
Shu HB* (2010). The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation.
J Immunol 184:6249-6255.
42. Lei CQ, Zhong B, Zhang Y, Zhang J,
Shu HB* (2010). GSK3b regulates virus-triggered IRF3 activation and cellular antiviral response by promoting TBK1 activation.
Immunity 33:878-889.
43. Li Q, Yan J, Mao AP, Li C, Ran Y,
Shu HB*, Wang YY
* (2011). Tripartite motif 8 (TRIM8) modulates TNFa- and IL-1b-triggered NF-kB activation by targeting TAK1 for K63-linked polyubiquitination.
P Natl Acad Sci USA 108:19341-19346.
44. Ran Y, Liu TT, Zhou Q, Li S, Mao AP, Li Y, Liu LJ, Cheng JK,
Shu HB* (2011). SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation.
J Mol Cell Biol 2:283-292.
45. Liu Y, Song R, Gao Y, Li Y, Wang S, Liu HY, Wang Y, Hu YH,
Shu HB* (2012). Protein kinase C-δ negatively regulates T cell receptor-induced NF-kB activation by inhibiting the assembly of CARMA1 signalosome.
J Biol Chem 287:20081-20087.
46. He X, Li Y, Li C, Liu LJ, Zhang XD, Liu Y,
Shu HB* (2012).USP2a negatively regulates IL-1β- and virus-induced NF-κB activation by deubiquitinating TRAF6.
J Mol Cell Biol 5:39-47.
47. Zhang J, Hu MM, Wang YY,
Shu HB* (2012). TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination.
J Biol Chem 287:28646-28655.
48. Li Y, Chen R, Zhou Q, Xu Z, Li C, Wang S, Mao A, Zhang X, He W,
Shu HB* (2012). LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection.
P Natl Acad Sci USA 109:11770-11775.
49. Wang YY
*, Ran Y,
Shu HB* (2012).Linear ubiquitination of NEMO brakes the antiviral response.
Cell Host Microbe 12:129-131.
50. Chen R, Li M, Zhang Y, Zhou Q,
Shu HB* (2012). The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation.
P Natl Acad Sci USA 109:14128-14133.
51. Zheng H, Li Q, Chen R, Zhang J, Ran Y, He X, Li S,
Shu HB* (2012).Dual-specificity phosphatase 14 (DUSP14) negatively regulates TNF-a and IL-1-induced NF-κB activation by dephosphorylating the protein kinase TAK1.
J Biol Chem 288:819-825.
52. Yang Y, Liao B, Wang S, Jin Y,
Shu HB*, Wang YY*. (2013). The E3 ubiquitin ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation.
PNAS 110(13):5115-20.
53. Li C, Wei J, Li Y, He X, Zhou Q, Yan J, Zhang J, Liu Y, Liu Y,
Shu HB* (2013). Transmembrane protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase-4 activation and apoptosis.
J Biol Chem
54. Lei CQ, Zhang Y, Xia T, Jiang LQ, Zhong B,
Shu HB* (2013). FoxO1 Negatively Regulates Cellular Antiviral Response by Promoting Degradation of IRF3.
J Biol Chem 288:12596-12604.
55. Chen H, Li Y, Zhang J, Ran Y, Wei J, Yang Y,
Shu HB* (2013). RAVER1 is a coactivator of MDA5-mediated cellular antiviral response.
J Mol Cell Biol 5:111-119.
发表著作
舒红兵 主编，《抗病毒天然免疫》，科学出版社，北京，2009。
